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KMID : 0376119930200010099
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Medical Journal of the Red Cross Hospital
1993 Volume.20 No. 1 p.99 ~ p.102
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Intravenous Ketamine for Prevention of Hypotenison during Spinal anesthesia
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Abstract
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hypotension is a frequent complication during spinal anesthesia and mechanisms are a decrease in total peripheral vascular resistance, a decrease in cardiac output of a combination of both due to paralysis of preganglionic sympathetic fibers,
while
ketamine induces activation of the sympathetic nervous system. The aim of our study was to compare blood pressure changes in patients who received either fentanyl or ketamine during spinal anesthesia. Thirty. patients (ASA I-II) scheduled to
undergo
spinal anesthesia for operation of lower extremity were allocated to receive either ketamine or rentanyl intravenously during the operation. Immediately before anesthesia, 10 ml/kg BW of Latate Ringer's solution was administered intravenously
Patients
received either fentanyl 2.5㎍/kg/60 min intravenously after anesthesia or ketamine 0.5 mg/kg/30 min intravenously after anesthesia.
If the reduction in systolic blood pressure exceeded 30%, patients were administered ephedrine 20 mg intravenously. The systolic blood pressure was lower in the fentanyl group than in the ketamine group(P<0.05). We that during spinal anesthesia
patients can in part be kept hemodynamically stable by intravenous administration of ketamine.
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